Protective Effects of Resveratrol against UVA-Induced Damage in ARPE19 Cells
Identifieur interne : 000026 ( Main/Exploration ); précédent : 000025; suivant : 000027Protective Effects of Resveratrol against UVA-Induced Damage in ARPE19 Cells
Auteurs : Chi-Ming Chan [Taïwan] ; Cheng-Hua Huang [Taïwan] ; Hsin-Ju Li ; Chien-Yu Hsiao [Taïwan] ; Ching-Chieh Su [Taïwan] ; Pei-Lan Lee ; Chi-Feng HungSource :
- International Journal of Molecular Sciences ; 2015.
English descriptors
- KwdEn :
- Cell Line, Cell Survival (drug effects), Cell Survival (radiation effects), Cyclooxygenase 2 (metabolism), Extracellular Signal-Regulated MAP Kinases (metabolism), Humans, Hydrogen Peroxide (metabolism), JNK Mitogen-Activated Protein Kinases (metabolism), Oxidative Stress (drug effects), Oxidative Stress (radiation effects), Phosphorylation (drug effects), Phosphorylation (radiation effects), Radiation-Protective Agents (pharmacology), Retinal Pigment Epithelium (cytology), Retinal Pigment Epithelium (metabolism), Stilbenes (pharmacology), Ultraviolet Rays, p38 Mitogen-Activated Protein Kinases (metabolism).
- MESH :
- chemical , metabolism : Cyclooxygenase 2, Extracellular Signal-Regulated MAP Kinases, Hydrogen Peroxide, JNK Mitogen-Activated Protein Kinases, p38 Mitogen-Activated Protein Kinases.
- cytology : Retinal Pigment Epithelium.
- drug effects : Cell Survival, Oxidative Stress, Phosphorylation.
- metabolism : Retinal Pigment Epithelium.
- chemical , pharmacology : Radiation-Protective Agents, Stilbenes.
- radiation effects : Cell Survival, Oxidative Stress, Phosphorylation.
- Cell Line, Humans, Ultraviolet Rays.
Abstract
Ultraviolet radiation, especially UVA, can penetrate the lens, reach the retina, and induce oxidative stress to retinal pigment epithelial (RPE) cells. Even though it is weakly absorbed by protein and DNA, it may trigger the production of reactive oxygen species (ROS) and generate oxidative injury; oxidative injury to the retinal pigment epithelium has been implicated to play a contributory role in age-related macular degeneration (AMD). Studies showed that resveratrol, an abundant and active component of red grapes, can protect several cell types from oxidative stress. In this study, adult RPE cells being treated with different concentrations of resveratrol were used to evaluate the protective effect of resveratrol on RPE cells against UVA-induced damage. Cell viability assay showed that resveratrol reduced the UVA-induced decrease in RPE cell viability. Through flow cytometry analysis, we found that the generation of intracellular H2O2 induced by UVA irradiation in RPE cells could be suppressed by resveratrol in a concentration-dependent manner. Results of Western blot analysis demonstrated that resveratrol lowered the activation of UVA-induced extracellular signal-regulated kinase, c-jun-NH2 terminal kinase and p38 kinase in RPE cells. In addition, there was also a reduction in UVA-induced cyclooxygenase-2 (COX-2) expression in RPE cells pretreated with resveratrol. Our observations suggest that resveratrol is effective in preventing RPE cells from being damaged by UVA radiation, and is worth considering for further development as a chemoprotective agent for the prevention of early AMD.
Url:
DOI: 10.3390/ijms16035789
PubMed: 25775159
PubMed Central: 4394506
Affiliations:
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E-Mails:<email>m212092001@tmu.edu.tw</email> (C.-M.C.);<email>infection@cgh.org.tw</email> (C.-H.H.);<email>suk.ccsu@gmail.com</email> (C.-C.S.)</nlm:aff></affiliation><affiliation wicri:level="1"><nlm:aff id="af3-ijms-16-05789">Department of Internal Medicine, Cathay General Hospital, Taipei 10630, Taiwan</nlm:aff><country xml:lang="fr">Taïwan</country><wicri:regionArea>Department of Internal Medicine, Cathay General Hospital, Taipei 10630</wicri:regionArea><wicri:noRegion>Taipei 10630</wicri:noRegion></affiliation></author><author><name sortKey="Li, Hsin Ju" sort="Li, Hsin Ju" uniqKey="Li H" first="Hsin-Ju" last="Li">Hsin-Ju Li</name><affiliation><nlm:aff id="af4-ijms-16-05789">Department of Chemstry, Fu Jen Catholic University, New Taipei City 24205, Taiwan; E-Mail:<email>sakumanatsumi@gmail.com</email></nlm:aff></affiliation></author><author><name sortKey="Hsiao, Chien Yu" sort="Hsiao, Chien Yu" uniqKey="Hsiao C" first="Chien-Yu" last="Hsiao">Chien-Yu Hsiao</name><affiliation><nlm:aff id="af5-ijms-16-05789">Department of Nutrition and Health Sciences, Chang Gung University of Science and Technology, Kweishan, Taoyuan 33303, Taiwan; 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E-Mails:<email>m212092001@tmu.edu.tw</email> (C.-M.C.);<email>infection@cgh.org.tw</email> (C.-H.H.);<email>suk.ccsu@gmail.com</email> (C.-C.S.)</nlm:aff></affiliation><affiliation wicri:level="1"><nlm:aff id="af2-ijms-16-05789">Department of Ophthalmology, Cardinal Tien Hospital, Hsiendian, New Taipei City 23148, Taiwan</nlm:aff><country xml:lang="fr">Taïwan</country><wicri:regionArea>Department of Ophthalmology, Cardinal Tien Hospital, Hsiendian, New Taipei City 23148</wicri:regionArea><wicri:noRegion>New Taipei City 23148</wicri:noRegion></affiliation></author><author><name sortKey="Huang, Cheng Hua" sort="Huang, Cheng Hua" uniqKey="Huang C" first="Cheng-Hua" last="Huang">Cheng-Hua Huang</name><affiliation><nlm:aff id="af1-ijms-16-05789">School of Medicine, Fu Jen Catholic University, New Taipei City 24205, Taiwan; E-Mails:<email>m212092001@tmu.edu.tw</email> (C.-M.C.);<email>infection@cgh.org.tw</email> (C.-H.H.);<email>suk.ccsu@gmail.com</email> (C.-C.S.)</nlm:aff></affiliation><affiliation wicri:level="1"><nlm:aff id="af3-ijms-16-05789">Department of Internal Medicine, Cathay General Hospital, Taipei 10630, Taiwan</nlm:aff><country xml:lang="fr">Taïwan</country><wicri:regionArea>Department of Internal Medicine, Cathay General Hospital, Taipei 10630</wicri:regionArea><wicri:noRegion>Taipei 10630</wicri:noRegion></affiliation></author><author><name sortKey="Li, Hsin Ju" sort="Li, Hsin Ju" uniqKey="Li H" first="Hsin-Ju" last="Li">Hsin-Ju Li</name><affiliation><nlm:aff id="af4-ijms-16-05789">Department of Chemstry, Fu Jen Catholic University, New Taipei City 24205, Taiwan; E-Mail:<email>sakumanatsumi@gmail.com</email></nlm:aff></affiliation></author><author><name sortKey="Hsiao, Chien Yu" sort="Hsiao, Chien Yu" uniqKey="Hsiao C" first="Chien-Yu" last="Hsiao">Chien-Yu Hsiao</name><affiliation><nlm:aff id="af5-ijms-16-05789">Department of Nutrition and Health Sciences, Chang Gung University of Science and Technology, Kweishan, Taoyuan 33303, Taiwan; E-Mail:<email>mozart@gw.cgust.edu.tw</email></nlm:aff></affiliation><affiliation wicri:level="1"><nlm:aff id="af6-ijms-16-05789">Research center for Industry of Human Ecology, Chang Gung University of Science and Technology, Kweishan, Taoyuan 33303, Taiwan</nlm:aff><country xml:lang="fr">Taïwan</country><wicri:regionArea>Research center for Industry of Human Ecology, Chang Gung University of Science and Technology, Kweishan, Taoyuan 33303</wicri:regionArea><wicri:noRegion>Taoyuan 33303</wicri:noRegion></affiliation></author><author><name sortKey="Su, Ching Chieh" sort="Su, Ching Chieh" uniqKey="Su C" first="Ching-Chieh" last="Su">Ching-Chieh Su</name><affiliation><nlm:aff id="af1-ijms-16-05789">School of Medicine, Fu Jen Catholic University, New Taipei City 24205, Taiwan; E-Mails:<email>m212092001@tmu.edu.tw</email> (C.-M.C.);<email>infection@cgh.org.tw</email> (C.-H.H.);<email>suk.ccsu@gmail.com</email> (C.-C.S.)</nlm:aff></affiliation><affiliation wicri:level="1"><nlm:aff id="af7-ijms-16-05789">Graduate Institute of Applied Science and Engineering, Fu Jen Catholic University, New Taipei City 24205, Taiwan</nlm:aff><country xml:lang="fr">Taïwan</country><wicri:regionArea>Graduate Institute of Applied Science and Engineering, Fu Jen Catholic University, New Taipei City 24205</wicri:regionArea><wicri:noRegion>New Taipei City 24205</wicri:noRegion></affiliation><affiliation wicri:level="1"><nlm:aff id="af8-ijms-16-05789">Department of Internal Medicine, Cardinal Tien Hospital, Hsiendian, New Taipei City 23148, Taiwan</nlm:aff><country xml:lang="fr">Taïwan</country><wicri:regionArea>Department of Internal Medicine, Cardinal Tien Hospital, Hsiendian, New Taipei City 23148</wicri:regionArea><wicri:noRegion>New Taipei City 23148</wicri:noRegion></affiliation></author><author><name sortKey="Lee, Pei Lan" sort="Lee, Pei Lan" uniqKey="Lee P" first="Pei-Lan" last="Lee">Pei-Lan Lee</name><affiliation><nlm:aff id="af9-ijms-16-05789">Slone Epidemiology Center, Boston University, Boston, MA 02215, USA; E-Mail:<email>hlittlem@gmail.com</email></nlm:aff></affiliation></author><author><name sortKey="Hung, Chi Feng" sort="Hung, Chi Feng" uniqKey="Hung C" first="Chi-Feng" last="Hung">Chi-Feng Hung</name><affiliation><nlm:aff id="af1-ijms-16-05789">School of Medicine, Fu Jen Catholic University, New Taipei City 24205, Taiwan; E-Mails:<email>m212092001@tmu.edu.tw</email> (C.-M.C.);<email>infection@cgh.org.tw</email> (C.-H.H.);<email>suk.ccsu@gmail.com</email> (C.-C.S.)</nlm:aff></affiliation></author></analytic><series><title level="j">International Journal of Molecular Sciences</title><idno type="e-ISSN">1422-0067</idno><imprint><date when="2015">2015</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Cell Line</term><term>Cell Survival (drug effects)</term><term>Cell Survival (radiation effects)</term><term>Cyclooxygenase 2 (metabolism)</term><term>Extracellular Signal-Regulated MAP Kinases (metabolism)</term><term>Humans</term><term>Hydrogen Peroxide (metabolism)</term><term>JNK Mitogen-Activated Protein Kinases (metabolism)</term><term>Oxidative Stress (drug effects)</term><term>Oxidative Stress (radiation effects)</term><term>Phosphorylation (drug effects)</term><term>Phosphorylation (radiation effects)</term><term>Radiation-Protective Agents (pharmacology)</term><term>Retinal Pigment Epithelium (cytology)</term><term>Retinal Pigment Epithelium (metabolism)</term><term>Stilbenes (pharmacology)</term><term>Ultraviolet Rays</term><term>p38 Mitogen-Activated Protein Kinases (metabolism)</term></keywords><keywords scheme="MESH" type="chemical" qualifier="metabolism" xml:lang="en"><term>Cyclooxygenase 2</term><term>Extracellular Signal-Regulated MAP Kinases</term><term>Hydrogen Peroxide</term><term>JNK Mitogen-Activated Protein Kinases</term><term>p38 Mitogen-Activated Protein Kinases</term></keywords><keywords scheme="MESH" qualifier="cytology" xml:lang="en"><term>Retinal Pigment Epithelium</term></keywords><keywords scheme="MESH" qualifier="drug effects" xml:lang="en"><term>Cell Survival</term><term>Oxidative Stress</term><term>Phosphorylation</term></keywords><keywords scheme="MESH" qualifier="metabolism" xml:lang="en"><term>Retinal Pigment Epithelium</term></keywords><keywords scheme="MESH" type="chemical" qualifier="pharmacology" xml:lang="en"><term>Radiation-Protective Agents</term><term>Stilbenes</term></keywords><keywords scheme="MESH" qualifier="radiation effects" xml:lang="en"><term>Cell Survival</term><term>Oxidative Stress</term><term>Phosphorylation</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Cell Line</term><term>Humans</term><term>Ultraviolet Rays</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><p>Ultraviolet radiation, especially UVA, can penetrate the lens, reach the retina, and induce oxidative stress to retinal pigment epithelial (RPE) cells. Even though it is weakly absorbed by protein and DNA, it may trigger the production of reactive oxygen species (ROS) and generate oxidative injury; oxidative injury to the retinal pigment epithelium has been implicated to play a contributory role in age-related macular degeneration (AMD). Studies showed that resveratrol, an abundant and active component of red grapes, can protect several cell types from oxidative stress. In this study, adult RPE cells being treated with different concentrations of resveratrol were used to evaluate the protective effect of resveratrol on RPE cells against UVA-induced damage. Cell viability assay showed that resveratrol reduced the UVA-induced decrease in RPE cell viability. Through flow cytometry analysis, we found that the generation of intracellular H<sub>2</sub>O<sub>2</sub> induced by UVA irradiation in RPE cells could be suppressed by resveratrol in a concentration-dependent manner. Results of Western blot analysis demonstrated that resveratrol lowered the activation of UVA-induced extracellular signal-regulated kinase, c-jun-NH<sub>2</sub> terminal kinase and p38 kinase in RPE cells. In addition, there was also a reduction in UVA-induced cyclooxygenase-2 (COX-2) expression in RPE cells pretreated with resveratrol. Our observations suggest that resveratrol is effective in preventing RPE cells from being damaged by UVA radiation, and is worth considering for further development as a chemoprotective agent for the prevention of early AMD.</p></div></front><back><div1 type="bibliography"><listBibl><biblStruct><analytic><author><name sortKey="Murthy, R K" uniqKey="Murthy R">R.K. Murthy</name></author><author><name sortKey="Ravi, K" uniqKey="Ravi K">K. Ravi</name></author><author><name sortKey="Balaiya, S" uniqKey="Balaiya S">S. Balaiya</name></author><author><name sortKey="Brar, V S" uniqKey="Brar V">V.S. 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Di Battista</name></author></analytic></biblStruct></listBibl></div1></back></TEI><affiliations><list><country><li>Taïwan</li></country></list><tree><noCountry><name sortKey="Hung, Chi Feng" sort="Hung, Chi Feng" uniqKey="Hung C" first="Chi-Feng" last="Hung">Chi-Feng Hung</name><name sortKey="Lee, Pei Lan" sort="Lee, Pei Lan" uniqKey="Lee P" first="Pei-Lan" last="Lee">Pei-Lan Lee</name><name sortKey="Li, Hsin Ju" sort="Li, Hsin Ju" uniqKey="Li H" first="Hsin-Ju" last="Li">Hsin-Ju Li</name></noCountry><country name="Taïwan"><noRegion><name sortKey="Chan, Chi Ming" sort="Chan, Chi Ming" uniqKey="Chan C" first="Chi-Ming" last="Chan">Chi-Ming Chan</name></noRegion><name sortKey="Hsiao, Chien Yu" sort="Hsiao, Chien Yu" uniqKey="Hsiao C" first="Chien-Yu" last="Hsiao">Chien-Yu Hsiao</name><name sortKey="Huang, Cheng Hua" sort="Huang, Cheng Hua" uniqKey="Huang C" first="Cheng-Hua" last="Huang">Cheng-Hua Huang</name><name sortKey="Su, Ching Chieh" sort="Su, Ching Chieh" uniqKey="Su C" first="Ching-Chieh" last="Su">Ching-Chieh Su</name><name sortKey="Su, Ching Chieh" sort="Su, Ching Chieh" uniqKey="Su C" first="Ching-Chieh" last="Su">Ching-Chieh Su</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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